Research and Studies

The EOC has over 40 patients on various ExOnc studies each day, helping the EOC to be one of the largest ExOnc research centers in the world. Some of the current studies include:

Current Studies:

EXERT-BCN

Based on the success of EXERT-BC, this protocol utilizes the first dose escalated resistance training regimen in breast cancer patients and adds a low-carb, high quality nutrition regimen that avoids the drudgery of calorie counting. 

EXERT-C

This is the EOC master study where patients with all types of cancer will undergo a strength and resistance training workout to improve their strength, mobility, muscle mass, balance, quality of life, and functional capacity. 

NEO-CRT

In this novel study, we are assessing a tiered exercise programs that varies on a daily basis based on chemotherapy dosing and performance status in patients undergoing neoadjuvant FOLFIRINOX prior to whipple surgery for pancreatic cancer The study also includes monthly proteomics and metabolomics labs, along with assessment of microbiome. 

EXERT-BCH

What is the optimal exercise regimen to increase hypertrophy and improve body composition in women with breast cancer? EXERT-BCH is one step closer to answering this question. EXERT-BCH is current enrolling women with breast cancer and at least 3 month experience in resistance training.

Past Research:

Review of Nutrition Guidelines and Evidence on Diet and Survival Outcomes for Cancer Survivors: Call for Integrating Nutrition into Oncology Care

Z Li, X Ding, Y Chen, L Keaver, CE Champ, CL Fink, SC Lebovits, …

The Journal of Nutrition

2024

EXERT‐BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer

DJ Carpenter, C Peluso, C Hilton, F Velasquez, A Annichine, K Matsko, …

Cancer Medicine 13 (5), e7001

2024

The Relationship of the FMS to Anthropometric Markers in Women with Breast Cancer

J Rosenberg, D Carpenter, C Peluso, A Diaz, CE Champ

International Journal of Exercise Science: Conference Proceedings 9 (12), 37

2024

EXERT-BC: Prospective Study of an Exercise Regimen After Treatment for Breast Cancer

CE Champ, C Peluso, DJ Carenter, J Rosenberg, F Velasquez, …

Sports Medicine International Open 8 (continuous publication)

2024

EXERT-BC: A prospective study of an exercise regimen designed to improve functional mobility, body composition, and strength after treatment for breast cancer.

C Champ, DJ Carpenter, C Peluso, C Hilton, F Velasquez, S Beriwal

JCO Oncology Practice 19 (11_suppl), 494-494

2024

Feasibility and metabolic effects of a 5: 2 fasting intervention in women with breast cancer during radiotherapy

RJ Klement, J Figueroa, M Weigel, CE Champ, S Ok, RA Sweeney

Holistic Integrative Oncology 2 (1), 35

2023

Resistance training for patients with cancer: A conceptual framework for maximizing strength, power, functional mobility, and body composition to optimize health and outcomes

CE Champ, DJ Carpenter, AK Diaz, J Rosenberg, BG Ackerson, PN Hyde

Sports Medicine 53 (1), 75-89

 

2023

Comment on “the effect of resistance training on body composition during and after cancer treatment: A systematic review and meta-analysis”

CE Champ, J Rosenberg, BM Nakfoor, PN Hyde

Sports Medicine 52 (7), 1721-1722

 

2023

In Regard to Schumacher et al.

DJ Carpenter, AK Diaz, S Beriwal, PN Hyde, CE Champ

International Journal of Radiation Oncology, Biology, Physics 113 (1), 233-234

 

2023

Dietary-induced ketogenesis: adults are not children

K Porper, L Zach, Y Shpatz, B Ben-Zeev, M Tzadok, E Jan, A Talianski, …

Nutrients 13 (9), 3093

 

2022

A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma

K Porper, Y Shpatz, L Plotkin, RG Pechthold, A Talianski, CE Champ, …

Journal of neuro-oncology 153 (3), 487-496

 

2022

Quantity of resistance exercise for breast cancer patients: does the dose match the objective?

J Rosenberg, PN Hyde, WS Yancy Jr, KM Ford, CE Champ

The Journal of Strength & Conditioning Research 35 (5), 1467-1476

 

2021

A systematic review of home-based dietary interventions during radiation therapy for cancer

TH Allenby, ML Crenshaw, K Mathis, CE Champ, NL Simone, KH Schmitz, …

Technical Innovations & Patient Support in Radiation Oncology 16, 10-16

 

2021

Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients

RJ Klement, CE Champ, U Kämmerer, PS Koebrunner, K Krage, …

Breast Cancer Research 22, 1-14

 

2021

The effect of body mass index (BMI) on survival in patients with breast cancer and obesity-associated conditions.

KB Caddell, Y Ren, A Sampathkumar, CA Almond, OL Ladipo, CE Champ, …

Journal of Clinical Oncology 38 (29_suppl), 203-203

 

2021

Assessing successful completion of calorie restriction studies for the prevention and treatment of cancer

CE Champ, RJ Klement

Nutrition 78, 110829

 

2021

Nutrition in cancer: evidence and equality

CP Haskins, CE Champ, R Miller, MAL Vyfhuis

Advances in Radiation Oncology 5 (5), 817-823

 

2021

Exercise and patients with cancer—is it time to get heavier with the dose?

CE Champ, WS Yancy

JAMA oncology 6 (2), 301-301

 

2021

Problems associated with a highly artificial ketogenic diet: Letter to the Editor Re: van der Louw EJTM, Olieman JF, van den Bemt PMLA, et al. ‘Ketogenic diet …

RJ Klement, RA Sweeney, EC Gross, CE Champ

Therapeutic advances in medical oncology 11, 1758835919879268

2021

Big data from small devices: the future of smartphones in oncology

JM Purswani, AP Dicker, CE Champ, M Cantor, N Ohri

Seminars in radiation oncology 29 (4), 338-347

 

2021

Meat, eggs, full-fat dairy, and nutritional boogeymen: Does the way in which animals are raised affect health differently in humans?

CP Haskins, G Henderson, CE Champ

Critical reviews in food science and nutrition 59 (17), 2709-2719

 

2020

Metabolic Risk Factors for the Development of Radiation Pneumonitis in Stage III Non-Small Cell Lung Cancer (NSCLC)

NA Iarrobino, BS Gill, ME Bernard, MV Mishra, CE Champ

International Journal of Radiation Oncology, Biology, Physics 105 (1), E509-E510

 

2020

The impact of serum glucose in the treatment of locoregionally advanced pancreatic cancer

NA Iarrobino, BS Gill, RJ Klement, ME Bernard, CE Champ

American journal of clinical oncology 42 (9), 692-697

 

2020

Physician burnout and physician health: three simple suggestions for a complex problem

CE Champ, S Beriwal, RP Smith

Practical Radiation Oncology 9 (5), 297-299

2020

Maximizing polyphenol content to uncork the relationship between wine and cancer

CE Champ, A Kundu-Champ

Frontiers in Nutrition 6, 44

 

2020

High Body Mass Index Decreases Tumor Control in Locally Advanced Pancreatic Cancer Patients Treated with SBRT and Surgery

N Iarrobino, J Thomas, S Beriwal, M Bernard, C Champ

International Journal of Radiation Oncology* Biology* Physics 103 (5), E10

 

2020

In Regard to Britton et al

CE Champ, RJ Klement

International Journal of Radiation Oncology, Biology, Physics 103 (5), 1282-1283

2020

Hospitals lead by poor example: An assessment of snacks, soda, and junk food availability in Veterans Affairs hospitals

CE Champ, NA Iarrobino, CP Haskins

Nutrition 60, 70-73

 

2020

Data of unhealthy food availability in hospitals

CE Champ, NA Iarrobino, CP Haskins

Data in brief 21, 1738-1744

 

2020

Application of Bayesian evidence synthesis to modelling the effect of ketogenic therapy on survival of high grade glioma patients

RJ Klement, PS Bandyopadhyay, CE Champ, H Walach

Theoretical Biology and Medical Modelling 15, 1-15

 

2020

The Impact of Serum Glucose and Antidiabetic Agents in the Treatment of Locoregionally Advanced Pancreatic Cancer

NA Iarrobino, BS Gill, ME Bernard, CE Champ

International Journal of Radiation Oncology, Biology, Physics 102 (3), e74

 

2019

Targeting Tumor Metabolism with Statins during Treatment for Locoregionally Advanced Pancreatic Cancer

NA Iarrobino, BS Gill, ME Bernard, CE Champ

International Journal of Radiation Oncology, Biology, Physics 102 (3), S177

 

2019

Targeting tumor metabolism with statins during treatment for advanced-stage pancreatic cancer

NA Iarrobino, B Gill, ME Bernard, MV Mishra, CE Champ

American journal of clinical oncology 41 (11), 1125-1131

 

2019

Tracking steps in oncology: the time is now

JM Purswani, N Ohri, C Champ

Cancer management and research, 2439-2447

2019

The impact of serum glucose, anti-diabetic agents, and statin usage in non-small cell lung cancer patients treated with definitive chemoradiation

NA Iarrobino, BS Gill, M Bernard, RJ Klement, M Werner-Wasik, …

Frontiers in Oncology 8, 281

 

2019

Modeling the effects of ketogenic therapy on survival in patients with high grade glioma using Bayesian evidence synthesis

RJ Klement, PS Bandyopadhyay, CE Champ, H Walach

Aktuelle Ernährungsmedizin 43 (03), P60

 

2019

Assessing changes in the activity levels of breast cancer patients during radiation therapy

CE Champ, N Ohri, RJ Klement, M Cantor, S Beriwal, SM Glaser, …

Clinical breast cancer 18 (1), e1-e6

 

2019

(P095) Assessing Changes in the Activity Levels of Breast Cancer Patients During Radiation Therapy

CE Champ, N Ohri, M Cantor, RJ Klement, RP Smith

International Journal of Radiation Oncology, Biology, Physics 98 (2), E41

 

2019

Need for new review of article on ketogenic dietary regimes for cancer patients

RJ Klement, RD Feinman, EC Gross, CE Champ, DP D’Agostino, EJ Fine, …

Medical Oncology 34, 1-4

2019

Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels

RJ Klement, CE Champ

Brain 140 (3), e16-e16

 

2019

Anti-tumor effects of ketogenic diets in mice: a meta-analysis

RJ Klement, CE Champ, C Otto, U Kämmerer

PLoS One 11 (5), e0155050

 

2019

Fortifying the treatment of prostate cancer with physical activity

CE Champ, L Francis, RJ Klement, R Dickerman, RP Smith

Prostate Cancer 2016 (1), 9462975

 

2019

Commentary on “Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme”

CE Champ, RJ Klement

Strahlentherapie und Onkologie 191, 281-282

 

2018

Nutritional Approaches for Cancer Prevention and Treatment

CE Champ

Alternative and Complementary Therapies 20 (6), 302-305

 

2018

Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation

RJ Klement, CE Champ

Cancer and Metastasis Reviews 33 (1), 217-229

 

2018

Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme

CE Champ, JD Palmer, JS Volek, M Werner-Wasik, DW Andrews, …

Journal of neuro-oncology 117, 125-131

2018

Metformin: The sweet link between tumor genetics and metabolism

K Nowak, H Eldredge-Hindy, C Champ

OA Cancer 2 (1), 7

2018

Calorie or Carbohydrate Restriction? The Ketogenic Diet as Another Option for Supportive Cancer Treatment Reply

CE Champ, NL Simone

ONCOLOGIST 18 (9), 1057-1057

2018

Selectively starving cancer cells through dietary manipulation: methods and clinical implications

BA Simone, CE Champ, AL Rosenberg, AC Berger, DA Monti, AP Dicker, …

Future oncology 9 (7), 959-976

 

2018

Caloric restriction augments radiation efficacy in breast cancer

A Saleh, B Simone, J Palazzo, JE Savage, Y Sano, T Dan, L Jin, …

Cell cycle 12 (12), 1955-1963

2018

Dietary recommendations during and after cancer treatment: consistently inconsistent?

CE Champ, MV Mishra, TN Showalter, N Ohri, AP Dicker, NL Simone

Nutrition and cancer 65 (3), 430-439

2018

An evolutionary and mechanistic perspective on dietary carbohydrate restriction in cancer prevention

EJ Fine

Journal of Evolution and Health: A joint publication of the Ancestral Health …

21

2018

Nutrient restriction and radiation therapy for cancer treatment: when less is more

CE Champ, R Baserga, MV Mishra, L Jin, F Sotgia, MP Lisanti, RG Pestell, …

The oncologist 18 (1), 97-103

2018

Dietary Recommendations During Cancer Treatment: Consistently Inconsistent?

CE Champ, N Ohri, MV Mishra, TN Showalter, S Munro, AP Dicker, …

International Journal of Radiation Oncology, Biology, Physics 84 (3), S536

 

2018

Feasibility of dietary intervention in a breast cancer population.

CE Champ, PR Anne, TN Showalter, MJ Heersink, R Iacono, MV Mishra, …

Journal of Clinical Oncology 30 (15_suppl), e11505-e11505

 

2018

Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data?

CE Champ, JS Volek, J Siglin, L Jin, NL Simone

International journal of breast cancer 2012 (1), 506868

 

2018